Interceptor® Plus (milbemycin oxime/praziquantel)

You and your dog go everywhere. And, wherever you travel, you can trust the broad-spectrum parasite protection of Interceptor® Plus (milbemycin oxime/praziquantel). Protects against 5 threats

Approved for dogs and puppies two pounds of body weight or greater and six weeks of age and older, just one chicken-flavored chew each month protects your dog against five common (and potentially deadly) parasites:

  • Heartworm disease (Dirofilaria immitis)
  • Hookworm (Ancylostoma caninum)
  • Roundworm (Toxocara canis, Toxascaris leonina)
  • Whipworm (Trichuris vulpis)
  • Adult tapeworm (Echinococcus multilocularis, Echinococcus granulosus, Taenia pisiformis)

Is Interceptor Plus right for your dog? Interceptor Plus is ideal for active dogs who spend lots of time outdoors, love trips to the dog park or frequently visit boarding or grooming facilities. What’s more, Interceptor Plus is a great value. You gain broad-spectrum parasite control plus the flexibility to tailor flea and tick control to the season or whenever it’s needed. And finally, Interceptor Plus is easy to dose – a soft chew flavored with real chicken, over 96% of dogs willingly accept it.

Interceptor Plus – Choose The Chew With More Protection Than Heartgard® Plus (ivermectin/pyrantel)

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Five key threats to your dog’s health Heartworm disease1

  • Heartworms are transmitted by mosquitoes and infection in dogs has been reported in all 50 states
  • Symptoms include coughing, sluggishness and difficulty breathing, although some dogs may show no signs at all.


  • A common intestinal parasite, as many as 29.8% of shelter dogs in the U.S. were infected in one study2
  • Can be transmitted in many ways: ingestion of infected intermediate hosts, soil or feces, by microscopic larvae penetrating the pads of a dog’s paws or as pups via their mother’s milk3,4
  • Symptoms may include bloody diarrhea, weight loss and anemia3


  • As many as 12.5% of shelter dogs in the U.S. have roundworms (T. canis)2
  • Nearly all puppies get roundworms from their mother through her milk5
  • Symptoms may include diarrhea, vomiting, stunted growth and bloated belly5
  • Heavy accumulation of roundworms in a puppy can cause death5


  • A common parasite, approximately 18.7% of shelter dogs in U.S. are infected2
  • Contracted by dogs ingesting infective eggs (from soil or other contaminated or infested matter where infective eggs are found)5
  • Symptoms may include bloody diarrhea, dehydration and anemia6


  • Typically acquired by ingesting tapeworm larvae residing in a host such as rabbits, rodents or fleas7
  • Tapeworm segments can show up in a dog’s feces or on the fur under its tail

To learn more about Interceptor Plus, talk to your veterinarian or visit us online. [link to]

Important Safety Information

Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Interceptor Plus, dogs should be tested for existing heartworm infections. The safety of Interceptor Plus has not been evaluated in dogs used for breeding or in lactating females. The following adverse reactions have been reported in dogs after administration of milbemycin oxime or praziquantel: vomiting, diarrhea, depression/lethargy, ataxia, anorexia, convulsions, weakness, and salivation.

1American Heartworm Society Current Canine Guidelines, 2014

2Blagburn, BL. August 2014. Proceedings of the American Association of Veterinary Parasitologists, 59th Annual Meeting. Abstract 65.

3CAPC Parasite Recommendations – Hookworms,, Accessed 18 Aug 2015.

4Bowman DD. 1999. Georgis’ parasitology for veterinarians. Eighth ed. Philadelphia: WB Saunders Company. p 183-186.

5CAPC – Roundworms,, Accessed 10 June 2015.

6CAPC – Whipworms, Accessed July 2015.

7CAPC – Cyclophyllidean Tapeworms,, Accessed Aug 2015.

8Blagburn, B. et al. 2012 Proceedings of the American Association of Veterinary Parasitologists, 57th Annual Meeting. Abstract 75.

Interceptor Plus, Elanco and the diagonal bar are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

© 2016 Eli Lilly and Company, its subsidiaries or affiliates.