Fill in the blank with Viralign 6

More Complete ProtectionFor years, the beef industry has relied on commonly used combination vaccines that include bovine viral diarrhea (BVD) virus 1a and 2 to cross protect against 1b.  At the same time, 1b has increased in predominance from 41 percent to 61 percent among BVD-positive calves and the incidence of BVD has not been reduced.1

Fill in the blanks with Viralign® 6, the first combination modified-live vaccine to provide targeted protection against all three major BVD viral strains, including 1a, 2 and 1b, the most predominant BVD subtype. More complete BVD protection means a calf is better able to fight off profit-robbing diseases—such as bovine respiratory disease  (BRD)—minimizing the economic impact. 

Viralign 6—Targeted protection means more complete protection

Viralign 6 includes antigens for all three of the most prevalent BVD viral strains and protects against bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) and parainfluenza-3 (PI-3) virus. Decades of research and industry experts have proven that:

  • 1b is the predominant BVD virus subtype1,2,3
  • BVD incidence has not been reduced1
  • BRD continues to be the most challenging, economically devastating health management issue facing producers today4,5,6,7
  • Cross protection has not been effective in providing an adequate level of protection against 1b1,3
  • Viralign 6 provides targeted protection against 1b, the most predominant BVD virus subtype

BVD virus 1b study summary—improved protection8

Review a summary of research evaluating the effect of a BVD 1b vaccine on health and performance when cattle are exposed to BVD 1b persistently infected calves

This first-of-its-kind vaccine enables low-volume, subcutaneous administration in cattle 5 months of age and older. Viralign 6 is available in convenient 10-dose and 50-dose bottles through veterinarians and animal-health distributors. Review the product label for more information and contact your Elanco sales representative or technical consultant.

Important Safety Information

The label contains complete use information, including cautions and warnings. Always read, understand and follow all label and use directions.

Precautions: Do not vaccinate pregnant cows or calves nursing pregnant cows since abortions may occur. Do not vaccinate within 21 days of slaughter.

For vaccination of healthy cattle five months of age or older. Dose: 2 mL subcutaneous in the side of neck. See insert for full instructions.

1Ridpath, J. F., G. Lovell, J. D. Neill, T. B. Hairgrove, B. Velayudhan, and R. Mock. 2011. Change in predominance of bovine viral diarrhea virus subgenotypes among samples sub­mitted to a diagnostic laboratory over a 20-year time span. J. Vet. Diagn. Invest. 23:185-193.

2Elanco Study No. BIOUS120010.

3Fulton, R. W., B. Hessman, B. J. Johnson, J. F. Ridpath, J. T. Saliki, L. J. Burge, D. Sjeklocha, A. W. Confer, R. A. Funk, and M. E. Payton. 2006. Evaluation of diagnostic tests used for detection of bovine viral diarrhea virus and prevalence of subtypes 1a, 1b, and 2a in persistently infected cattle entering a feedlot. JAVMA, Vol 228, No. 4.

4Edwards, A. J. 1996. Respiratory Diseases of Feedlot Cattle in the Central USA. Bovine Practitioner. 30:5-7.

5Galyean, M. L., L. J. Perino, and G. C. Duff. 1999. Interaction of Cattle Health/Immunity and Nutrition. J. Anim. Sci. 77:1120-1134.

6Loneragan, G. H., D. A. Dargatz, P. S. Morley, and M. A. Smith. 2001. Trends in Mortality Ratios Among Cattle in US Feedlots. J. Am. Vet. Med. Assoc. 219:1122-1127.

7Chirase, N. K. and L. W. Greene. 2001. Dietary zinc and manganese sources administered from the fetal stage onwards affect immune response of transit stressed and virus infected offspring steer calves. Animal Feed Science and Technology. 93:217-228.

8Elanco Study No. BIOUS120012.


Is cross protection partial protection?

Learn more about the predominance of subtype 1b.