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ATOPICA® (cyclosporine oral solution) USP MODIFIED

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Comfortis® (spinosad)

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EasySpot® (fipronil)

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Interceptor® (milbemycin oxime)

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Itrafungol™ (itraconazole oral solution)

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MilbeMite® OTIC Solution (milbemycin oxime)

Nocita® (bupivacaine liposome injectable suspension)

 4C 2016[1]

ONSIOR® Tablets for Cats (robenacoxib)

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ONSIOR® Injection (robenacoxib)

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ULTRA™ Fel-O-Vax®

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ULTRA™ Hybrid


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Zobuxa® (enrofloxacin)

Comfortis logo
Comfortis® (spinosad)

Trust Comfortis when you want fleas dead and gone

Number 1 recommended prescription oral flea-only medication.1

  • One Comfortis® (spinosad) tablet starts killing fleas in just 30 minutes and prevents and treats flea infestations in cats for a full 30 days.
  • Kill fleas before they lay eggs with a 90-day treatment plan using Comfortis and routinely thereafter to prevent reinfestation.

Proven protection against the threat of fleas

Comfortis offers proven protection that lasts:

  • Trusted — the first FDA-approved tablet that kills fleas and prevents flea infestations for a full month.
  • Proven to improve signs of flea allergy dermatitis (FAD) through its rapid action on fleas.
  • Long-lasting 30-day protection, even if your pet swims, bathes or grooms frequently
  • Convenient flavored tablet avoids mess. No need to isolate your cat from children or other pets after treatment.


The introduction of spinosad for use in agriculture resulted in the receipt of a Presidential Green Chemistry Challenge Award in 1999 from the U.S. Environmental Protection Agency2. The award was presented to Dow AgroSciences LLC in the category of “Designing Safer Chemicals” for the introduction of spinosad as an insect control product for use on crops. This award demonstrates that spinosad as a technology for insect control has a favorable environmental profile. This award is not relevant to the safety and efficacy of Comfortis, nor does it confer any environmental benefit to Comfortis.

Fleas: worse than you think

Even indoor cats can be faced with a flea infestation. A few fleas can turn into a major infestation if not treated quickly. Female fleas can lay 40 to 50 eggs a day.3

But it gets worse:4

  • Fleas may cause extreme discomfort for your cat: scratching, chewing, biting, fur loss and restlessness.
  • Severe infestations may cause anemia, particularly in young or older pets.
  • Fleas are the source of flea allergy dermatitis (FAD), a common veterinary skin condition.
  • Tapeworm infections may be transmitted by fleas.

To learn more about Comfortis for Cats, talk to your veterinarian or visit us online.


Comfortis kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), for one month, on cats and kittens 14 weeks of age and older and 4.1 pounds of body weight or greater.

Important Safety Information

Comfortis for cats: The most common adverse reaction recorded in clinical trials was vomiting. Other adverse reactions were: lethargy, decreased appetite, weight loss, and diarrhea. Use with caution with concomitant extra-label use of ivermectin. The safe use of Comfortis in breeding, pregnant, or lactating cats has not been evaluated. See Comfortis label for complete safety information.

1Elanco Animal Health, data on file.

2The Presidential Green Chemistry Challenge Awards Program, Summary of 1999 Award Entries and Recipients

3Rust, M. and Dryden, M. 1997. The Biology, Ecology, and Management of the Cat Flea. Annu Rev Entomol 42:451–73.

4CAPC,, Accessed Feb. 28, 2018.

Comfortis is a trademark of Elanco or its affiliates.