Master Guard®

A unique combination of killed and MLV antigens to provide respiratory and reproductive protection for your herd- including pregnant cows.

NUPLURA® PH

Modern Technology, Faster Protection

Scour Bos®

Scour Bos Delivers in Ways Others Can’t.

Titanium®

Prevention You Can Count On. Dependable Safety You Can Rely On.

Vira Shield®

The Optimal Choice for Your Entire Herd

Additional Elanco Cattle Vaccines

A range of options to help keep your herd healthy


Titanium®

Prevention You Can Count On. Dependable Safety You Can Rely On.

Unlike other respiratory disease vaccines, the Titanium vaccine portfolio does not impact feed intake or milk production, and results in little to no post-treatment side effects, so you can keep your cattle on track with health management solutions that don’t interrupt your day-to-day operations or affect your bottom line. 1,2


With its consistent proven BRD protection and competitive price point, Titanium provides you with an effective line of vaccines that makes sense for your health management protocols and budget.


Powerful immune response Titanium’s Modified Live Vaccine (MLV) combination vaccines are excellent stimulators of cell-mediated immunity.3 The portfolio includes nine formulations ranging from a single antigen to a five-way combination product, giving you the disease protecting combinations you need to safeguard your cattle.


Studies document that Titanium vaccines protect against one or more of the viruses, and bacteria associated with respiratory disease including:

  • BVD, types 1a and 2
  • IBR
  • PI3
  • BRSV
  • Five strains of Leptospira, including L. hardjo-bovis. 3-7


With USDA’s approval of four combination vaccines for nursing calves and pregnant cows, Titanium brand vaccines can now protect your whole herd against costly disease pathogens. Combinations currently approved for use in pregnant cows and nursing calves:

  • Titanium 5+PH-M
  • Titanium 5 L5 HB
  • Titanium 5
  • Titanium 4 L5


Titanium 5 + PH- M

Titanium 5 + PH-M delivers effective immune response against the bacteria (Mannheimia haemolytica and Pasteurella multocida) and viruses (BVD types 1 and 2, IBR, PI3 and BRSV) most associated with bovine respiratory disease (BRD) in a single vaccine for cattle as young as 2 months of age. 8-10


VIRUSES AND BACTERIA — While respiratory viruses can cause BRD on their own, they also can compromise the immune system that normally protects cattle against bacteria, allowing bacteria to attack their host and cause severe cases of BRD. Titanium 5 + PH-M offers a powerful one-two punch to the immune system to combat viruses and bacteria.

CONVENIENCE — Titanium 5 + PH-M offers the convenience and flexibility of a single vaccine that protects against BRD causing viruses and bacteria. Approved for use in cattle 2 months of age and older, Titanium 5 + PH-M is flexible enough to be incorporated into virtually any vaccine protocol.

PROVEN AND EFFECTIVE — Titanium 5 + PH-M is proven safe and effective for cattle at all stages of production, with no interference between the viral and bacterial components of the vaccine.

Keep your cattle healthy - You don’t have to choose one over the other — contact an Elanco representative or call your veterinarian to get BRD protection that doesn’t cost you performance.



For all vaccine products: The label contains complete use information, including cautions and warnings. Always read, understand and follow the label and use directions. Do not vaccinate within 21 days of slaughter.

Precautions: Do not use Titanium BRSV 3, Titanium 3 LP, Titanium 3, Titanium IBR LP and Titanium IBR in pregnant cows or in calves nursing pregnant cows. Abortions may result.

1 As measured by body temperature, feed intake, injection-site reaction or white blood cell count.
2 Terhaar, B. 2001. “Evaluating the effects of vaccine-induced stress on productivity.” Study No. TR-13. Published by Agri Laboratories Ltd.
3 Endsley, J. J., M. J. Quade, B. Terhaar, and J. A. Roth. 2002. “Bovine viral diarrhea virus type 1- and type 2-specific bovine T lymphocyte-subset responses following modified-live virus vaccination.” Vet. Ther. 3(4): 364-372.
4 Terhaar, B. 1999. “A comparison of Titanium 5 L5 and Bovishield 4 L5 following virulent infectious bovine rhinotracheitis virus challenge.” Study No. TR-04. Published by Agri Laboratories Ltd.
5 Elanco Animal Health. Data on File.
6 Ohnesorge, W. C. 1998. “Immunogenicity of a modified live bovine viral diarrhea virus, type 1 and type 2, vaccine following BVDV 890 (type 2) challenge.” Study No. 97-24.
7 “Immune response of calves to MLV and killed vaccines at branding and weaning – in the face of maternal antibodies.” Study No. TR-20. Published by Agri Laboratories Ltd.
8 Efficacy study for BRSV fraction to demonstrate compatibility of the BRSV component in APHIS product code: 45B9.20 (unlicensed). Study No. 2011-05 Rev. 1.
9 Porter, M. 2013. Field safety evaluation of bovine rhinotracheitis-virus diarrhea-parainfluenza3-respiratory syncytial virus vaccine, modified live virus, APHIS product code 1181.20 (establishment 213) in combination with Mannheimia haemolytica-Pasteurella multocida bacterin-toxoid, APHIS product code: G935.04 (establishment 315). Protocol No. 2011-01, Rev. 02.
10 Milliken, G. A. 2013. Mannheimia haemolytica efficacy studies demonstrating the absence of excessive interference of Titanium products with the Mannheimia haemolytica-Pasteurella multocida bacterin-toxoid.


Titanium is a trademark of Eli Lilly and Company or its affiliates.