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Comfortis® (spinosad)

Trust Comfortis when you want fleas dead and gone

Number 1 recommended prescription oral-flea only medication¹.

Fast Speed of Kill

  • Starts killing fleas in 30 minutes
  • Killed 100% of fleas in four hours
  • Kills fleas before they can lay eggs
  • Excellent flea kill for a full month

Kill fleas before they lay eggs with a 90-day treatment plan using Comfortis and routinely thereafter to prevent reinfestation.

Proven protection against the threat of fleas

Comfortis offers proven protection that lasts:

  • The first FDA-approved tablet that kills fleas and prevents flea infestations for a full month.
  • In a controlled laboratory study, the active ingredient in Comfortis (spinosad) killed 100% of fleas in 4 hours in dogs
  • Proven to improve signs of flea allergy dermatitis (FAD) through its rapid action on fleas
  • Long-lasting 30-day protection, even if your pet swims, bathes or grooms frequently
  • Convenient flavored tablet avoids mess. No need to isolate your dog from children or other pets after treatment


The introduction of spinosad for use in agriculture resulted in the receipt of a Presidential Green Chemistry Challenge Award in 1999 from the U.S. Environmental Protection Agency.2 The award was presented to Dow AgroSciences LLC in the category of “Designing Safer Chemicals” for the introduction of spinosad as an insect control product for use on crops. This award demonstrates that spinosad as a technology for insect control has a favorable environmental profile. This award is not relevant to the safety and efficacy of Comfortis, nor does it confer any environmental benefit to Comfortis.

Fleas: worse than you think

Even the most conscientious dog owner can be faced with a flea infestation. Your dog could be exposed in your home or backyard, on walks, or at the groomer or boarding kennel. A few fleas can turn into a major infestation if not treated quickly. Female fleas can lay 40 to 50 eggs a day.3
But it gets worse:4

  • Fleas may cause extreme discomfort for your dog: scratching, chewing, biting, fur loss and restlessness.
  • Severe infestations may cause anemia, particularly in young or older pets.
  • Fleas are the source of flea allergy dermatitis (FAD), a common veterinary skin condition.
  • Tapeworm infections may be transmitted by fleas.

To learn more about Comfortis, talk to your veterinarian or visit us online.

Comfortis 10lbs Pink FLeft HR2015


Comfortis kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), for one month, on dogs and puppies 14 weeks of age or older and 5 lbs of body weight or greater.

Important Safety Information

For dogs: The most common adverse reaction reported is vomiting. Other adverse reactions reported in decreasing order of frequency are: depression/lethargy, decreased appetite, incoordination, diarrhea, itching, trembling, excessive salivation and seizures. Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with Comfortis. Post-approval experience continues to support the safety of Comfortis when used concurrently with heartworm preventatives according to label directions. For dogs and puppies 14 weeks of age and older. Use with caution in breeding females and dogs with pre-existing epilepsy. The safe use of Comfortis in breeding males has not been evaluated. See Comfortis label for complete safety information.

1Elanco Animal Health, data on file.

2The Presidential Green Chemistry Challenge Awards Program, Summary of 1999 Award Entries and Recipients

3Rust, M. and Dryden, M. 1997. The Biology, Ecology, and Management of the Cat Flea. Annu Rev Entomol 42:451–73

4CAPC, Accessed Feb. 28, 2018.

Comfortis is a trademark of Elanco or its affiliates.