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ATOPICA® (cyclosporine capsules) USP MODIFIED

Bronchi-Shield® ORAL

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Capstar® (nitenpyram)

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Clomicalm® (clomipramine hydrochloride)

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Comfortis® (spinosad)

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Deramaxx® (deracoxib)

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Duramune®, Duramune Lyme® and LeptoVax®4

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Galliprant® (grapiprant tablets)

Interceptor® (milbemycin oxime)

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Interceptor® Plus (milbemycin oxime/praziquantel)

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Onsior® Tablets for Dogs (robenacoxib)

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Onsior® Injection (robenacoxib)

Osurnia® (florfenicol, terbinafine, betamethasone acetate)


Parastar® for Dogs

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Parastar® Plus (fipronil/cyphenothrin)

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Percorten®-V (desoxycorticosterone pivalate injectable suspension)

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Surolan® (miconazole nitrate, polymyxin B sulfate, prednisolone acetate)

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Trifexis® (spinosad + milbemycin oxime)

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ULTRA™ Duramune®

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Zobuxa® (enrofloxacin)

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Duramune®, Duramune Lyme® and LeptoVax®4

Duramune Lyme

The only Lyme vaccines in combinations, offering solutions for any protocol

Real-world results and combinations that offer
lower volume and fewer needle sticks for less
pain and more comfort


Trusted results you can rely on

  • 92.2% efficacy in a real world challenge study conducted in a highly endemic area1
  • 100% efficacy in a laboratory study2
  • Safe--even in Lyme-positive dogs3
  • Made with PureFilTM Technology, designed to reduce unwantd proteins and cellular debris

Duramune Lyme provides a broad antibody response to multiple Osps: OspA, OspB, OspC and many more4,5


Protection that Measures Up

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Lepto Vax 4

Innovative, tested and trusted

• The first 4-serovar vaccines to protect against emerging lepto serovars grippotyphosa and pomona
• Shown to be efficacious for spirochetemia against grippo and pomona by experimental challenge6
• In the largest-ever vaccine safety study7 — with 1.2 million dogs — Duramune products with Leptospira immunogens were no more likely to produce an adverse event than other vaccines, such as those for rabies
• Six standard 1 mL lepto vaccines and three ULTRATM Duramune 0.5 mL options

Unique Subunit4 Purification™ DESIGNED for enhanced safety and a COMFORTABLE injection


Choose ULTRATM Duramune Vaccines for Lepto Protection

This first and only 0.5 mL line available today. ULTRA vaccines were designed for a more comfortable injection with 50% less volume, but with the same protection that has made Duramune a trusted brand for more than 30 years.8

Millions of doses continue to provide outstanding results

With millions of doses administered, the effectiveness of these vaccines as a group is well-recognized. Vaccinating your patients regularly ensures frequent contact with dog owners and allows for updated risk assessment for changing threats.

Canine lepto vaccines from Elanco

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Duramune and LeptoVax vaccines are made with PureFil™ Technology, designed to reduce unwanted proteins and cellular debris.

Always read, understand and follow the label and use directions.


  1. Levy SA. Use of C6 ELISA test to evaluate the efficacy of a whole-cell bacterin for the prevention of naturally transmitted canine Borrelia burgdorferi infection. Vet Ther. 2002;3(4):420–424.

  2. Elanco Animal Health. Data on File.

  3. Levy, et al. Performance of a Borrelia burgdorferi bacterin in borreliosis-endemic areas. JAVMA. 1993; 202(11):1834-1838

  4. Chu HJ, Chavez LG, Blumer BM, Sebring RW, Wasmoen, TL, Acree WM. Immunogenicity and efficacy study of a commercial Borrelia burgdorferi bacterin. J Am Vet Med Assoc. 1992;201(3):403–411.

  5. Levy SA, Millership J, Glover S, Parker D, Hogan J, Heldorfer M, Ng T. Confirmation of Presence of Borrelia burgdorferi Outer Surface Protein C Antigen and Production of Antibodies to Borrelia burgdorferi Outer Surface Protein C in Dogs Vaccinated with a Whole-cell Borrelia burgdorferi Bacterin. The Journal of Applied Research in Veterinary Medicine. 2010 Jan 1;8(3):123.

  6. Elanco Animal Health. Data on file.

  7. Moore G, Guptil L, Ward M, et al. Adverse events diagnosed within three days of vaccine administration in dogs. JAVMA. 2005;227(7): 1102-1108.

  8. Elanco Animal Health. Data on File.

Duramune, Duramune Lyme, LeptoVax, ULTRA Duramune are trademarks of Elanco or its affiliates.