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ATOPICA® (cyclosporine capsules) USP MODIFIED

Bronchi-Shield® ORAL

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Clomicalm® (clomipramine hydrochloride)

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Comfortis® (spinosad)

Credelio® (lotilaner)

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Deramaxx® (deracoxib)

Duramune Lyme

Entyce® (capromorelin oral solution)

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Galliprant® (grapiprant tablets)

Interceptor® (milbemycin oxime)

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Interceptor® Plus (milbemycin oxime/praziquantel)

Nocita® (bupivacaine liposome injectable suspension)

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Onsior® Tablets for Dogs (robenacoxib)

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Onsior® Injection (robenacoxib)


Parastar® for Dogs

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Parastar® Plus (fipronil/cyphenothrin)

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Percorten®-V (desoxycorticosterone pivalate injectable suspension)

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Surolan® (miconazole nitrate, polymyxin B sulfate, prednisolone acetate)

Tanovea®-CA1 (rabacfosadine for injection)

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Trifexis® (spinosad + milbemycin oxime)

Ultra Duramune

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Zobuxa® (enrofloxacin)

Duramune Lyme


Seeing the blue dot show up on a Lyme test is frustrating for you and your clients. With Duramune Lyme®, you can confidently help stop Lyme disease before it starts.

  • Reduce the likelihood of positive results with the only Lyme vaccine that provided 92.2% efficacy against natural infection in a highly endemic area in a peer-reviewed study*1 and 100% efficacy against the disease in a laboratory setting2
  • Duramune Lyme contains multiple types of outer-surface proteins,3,4 not just OspA and OspC. It also comes in convenient combinations, which means fewer needle sticks to help prevent disease

*Based on available peer-reviewed studies.


Duramune Lyme reduces the likelihood of positive results. Seeing fewer blue dots is something dogs, owners and veterinarians can feel great about.


Vaccinating your canine patients regularly and comfortably ensures frequent, positive contact with their owners and updated risk assessments for changing threats such as Lyme disease.

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Click here to see the entire canine vaccine line and visit to learn more about the breadth and flexibility provided by Duramune Lyme and other vaccines in the Elanco portfolio.


Duramune Lyme

  • Is the only vaccine with an impressive 92.2% efficacy against natural infection in a highly endemic area1 and 100% efficacy in a laboratory study*2
  • Was shown to be safe in Lyme-positive dogs in a research study5
  • Contains multiple major types of outer-surface proteins (Osps) —including OspA, OspB, OspC and many others3,4
  • Has been shown to neutralize multiple field isolates of Borrelia burgdorferi3
  • Is the only Lyme vaccine available in convenient combinations to help reduce the number of needle sticks with effective protection
  • Is also available in ½ mL ULTRA Duramune® Lyme monovalent vaccine

*Based on available peer-reviewed studies.

The study was conducted in endemic area in the state of Connecticut.5

Reduce the likelihood of a positive Lyme test with Duramune Lyme.


You can count on the Elanco Vaccine Guarantee.

  • Our goal is to help you build stronger relationships with your clients; that’s why we guarantee the efficacy of our pet vaccine products
  • Reimbursement is up to 100% of standard, reasonable diagnostic and treatment of Lyme disease costs up to $5,000*

The Elanco Product Support Team is here to help you find solutions.

  • Our highly trained and experienced veterinarians, veterinary technicians and regional consulting veterinarians are available 24 hours a day, 7 days a week at 888-545-5973
  • Your Elanco sales representative is also here to help — call today

*If a dog immunized with an Elanco vaccine contracts a disease for which it should have been protected, based on the vaccine guidelines for best medicine published by the American Animal Hospital Association (AAHA).6 Please see the Elanco Vaccine Guarantee for full details.

Always read, understand and follow the label and use directions.

Elanco is proud to partner with Fear Free because it is the right thing to do for pets and othe people who care for them. We are proud to offer vaccines that allow veterinary professionals to provide Fear Free experiences to their patients.


  1. Levy SA. Use of a C6 ELISA test to evaluate the efficacy of a whole-cell bacterin for the prevention of naturally transmitted canine Borrelia burgdorferi. Vet Ther. 2002;3(4):420-424.
  2. Elanco Animal Health. Data on file.
  3. Chu HJ, Chavez LG Jr, Blumer BM, et al. Immunogenicity and efficacy study of a commercial Borrelia burgdorferi bacteria. J Am Vet Med Assoc. 1992;201(3):403-411.
  4. Levy SA, Millership J, Glover S, et al. Confirmation of presence of Borrelia burgdorferi outer surface protein C antigen and production of antibodies to Borrelia burgdorferi outer surface protein C in dogs vaccinated with a whole-cell Borrelia burgdorferi bacterin. Intern J Appl Res Vet Med. 2010;8(3):123-128.
  5. Levy SA, Lissman BA, Ficke CM. Performance of a Borrelia burgdorferi bacterin in borreliosis-endemic areas. J Am Vet Med Assoc. 1993;202(11):1834-8.
  6. Ford RB, Larson LJ, McClure KD, et al. 2017 AAHA canine vaccination guidelines. J Am Anim Hosp. 2017;53(5):243-51.

Duramune Lyme, LeptoVax, ULTRA Duramune, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.