A monthly chewable tablet for dogs that provides protection against three types of parasites in a single dose

When given once a month every month, Trifexis chewable tablets provide protection against three types of parasites for your dog.


  • Kills fleas and prevents infestations
  • Prevents heartworm disease
  • Treats and controls adult hookworm*, roundworm, and whipworm infections

*Ancylostoma canium

Trifexis is a beef flavored tablet that starts killing fleas in 30 minutes. It combines two powerful active ingredients that protect dogs safely and effectively against three types of dangerous parasites. Plus it is given orally, so there is no need to isolate the dog from other pets or children. Pet owners can play with their dog immediately after treatment. Trifexis is approved for use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.

Label information

Important safety information

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets.

Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.

The most common adverse reactions reported were vomiting, lethargy, pruritus, anorexia, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose. Puppies less than 14 weeks of age may experience a higher rate of vomiting.

View full product label for complete safety information.