Inteprity™ is a first-in-class, animal-use only, in-feed antibiotic for the prevention of mortality caused by necrotic enteritis associated with Clostridium perfringens in broiler chickens. It is a win-win solution that meets customer demands without compromising bird health.

Necrotic enteritis (NE) is a serious and constant threat to the health and welfare of poultry flocks. Due to the reduction of antibiotic use in poultry, the incidence of necrotic enteritis is on the rise, with daily mortality rates as high as 1 percent.1,2

As a tool used under the supervision of a veterinarian with a Veterinary Feed Directive, Inteprity supports bird health and well-being, as well as a responsible approach to antibiotic use.

Innovation backed by research

In studies conducted to determine effectiveness, Inteprity reduced mortality due to necrotic enteritis associated with C. perfringens from 76 to 93 percent versus the control group.3-6


Label Information

Inteprity Blue Bird labels

Feeding Directions

For the prevention of mortality caused by necrotic enteritis associated with Clostridium perfringens in broiler chickens:

  • Avilamycin is to be fed at 13.6 to 40.9 grams per ton of Type C medicated feed (15 to 45 ppm) as the sole ration for 21 consecutive days.

  • Feed to chickens that are at risk of developing, but not yet showing clinical signs of, necrotic enteritis associated with Clostridium perfringens.

Important Safety Information

  • CAUTION: Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.

  • To assure responsible antimicrobial drug use in broiler chickens, treatment administration must begin on or before 10 days of age.

  • The safety of avilamycin has not been established in chickens intended for breeding purposes.

  • Avilamycin has not been demonstrated to be effective in broiler chickens showing clinical signs of necrotic enteritis prior to the start of medication.

  • The Veterinary Feed Directive (VFD) expiration date must not exceed 90 days from the date of issuance. VFDs for avilamycin shall not be refilled.


  1. Williams, R. 2005. “Intercurrent coccidiosis and necrotic enteritis of chickens: rational, integrated disease management by maintenance of gut integrity.” Avian Pathol. 34.3: 159-180.
  2. Van Immerseel, F., Rood, J. et al. Jan. 2009. “Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens.” Trends Microbiol. 17.1: 32-36.
  3. Elanco Animal Health. Data on file.
  4.  Elanco Animal Health. Data on file.
  5.  Elanco Animal Health. Data on file
  6. Inteprity Freedom of Information Summary. (NADA 141-439) 


Inteprity™, Elanco® and the diagonal bar are all trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.


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