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Denagard® (tiamulin hydrogen fumarate)

Reduce the impact of two costly enteric diseases
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Hemicell® (β-mannanase)

β-Mannans: the problem component in soybean meal
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Kavault® (Avilamycin)

Reduce the incidence and overall severity of E. coli scours
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Pulmotil® (tilmicosin)

Control respiratory disease associated with Actinobacillus pleuropneumoniae or Pasteurella multocida
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Pulmotil® AC (tilmicosin phosphate)

Go with the flow to help control swine respiratory disease (SRD)*
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Skycis® (Narasin)

Ionophores: Innovation for a productive future
Tylan® Injection

Tylan® Injection

Effective at treating swine arthritis* in valuable breeding animals and finishers
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Tylan® Premix (Tylosin phosphate)

Proven control of ileitis* for dependable, reliable results

Tylan® Soluble (Tylosin tartrate)

Effective control of ileitis

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Hemicell® (β-mannanase)

β-Mannans: the problem component in soybean meal

β-Mannans (beta-galactomannans) are anti-nutritive fibers found in common feed ingredients, including soybean meal and other leguminous feeds.1-4 β-mannans have a molecular pattern similar to some pathogens, which triggers a Feed-Induced Immune Response (FIIR) in swine.5-9 This unnecessary innate immune system stimulation consumes energy10,11 and other valuable nutrients.

Hemicell breaks down β-mannans to spare energy for performance
Most enzyme products are energy-releasing enzymes—they "open up" feed components the animal is unable to access on its own. Hemicell is different: it's a unique and patented energy-sparing enzyme. By breaking down β-mannans in soybean meal,12-15 Hemicell minimizes production and economic losses caused by the FIIR from β-mannans, allowing more energy to be available for growth and performance.10,13,16,17

Hemicell is a unique and patented enzyme produced by fermentation of Bacillus lentus bacteria. The active ingredient is β-mannanase.

Recommended use program: Use Hemicell® in diets containing 12% SBM or higher.

Energy reduction (for high-energy diets): Improved performance allows for a reduction of dietary energy up to 45 kcal/lb.

Species: Swine

Dosage:

Hemicell-Dosage

Important Safety Information

The labels contain complete use information, including cautions and warnings. Always read, understand, and follow the labels and use directions.

1. Hsiao, H., Anderson, D. and Dale, N. 2006. ""Levels of β-mannan in Soybean Meal."" Poultry Sci. 85: 1430-1432.

2. Slominski, B. and Campbell, L. 1990. ""Non-starch Polysaccharides of Canola Meal: Quantification, Digestibility in Poultry and Potential Benefit of Dietary Enzyme Supplementation."" J. Sci. Food Agri. 53: 175-184.

3. Whistler, R. and Saarnio, J. 1957. ""Galactomannan from Soy Bean Hulls."" J. Am. Chem. Soc. 79: 6055-6057.

4. Dierick, N. 1989. ""Biotechnology aids to improve feed and feed digestion: Enzymes and fermentation."" Archives of Animal Nutrition (Berlin). 39:3: 241-246.

5. Song, W., Wang, G., Chen, L. et al. 1995. ""A Receptor Kinase-Like Protein Encoded by the Rice Disease Resistance Gene, Xa21."" Science. 270: 1806-1806.

6. Beutler, B., Jiang, Z., Georgel, P. et al. 2006. ""Genetic Analysis of Host Resistance: Toll-Like Receptor Signaling and Immunity at Large."" Annu. Rev. Immunol. 24: 353-389.

7. Ausubel, F. 2005. ""Are innate immune signaling pathways in plants and animals conserved?"" Nature Immunol. 6(10): 973-979.

8. Didierlaurent, A., Simonet, M. and Sirard, J-C. 2005. ""Innate and acquired plasticity of the intestinal immune system."" Cellular and Molecular Life Sciences. 62: 1285-1287.

9. Stahl, P. and Ezekowitz, R. 1998. ""The mannose receptor is a pattern recognition receptor involved in host defense."" Curr. Opin. Immunol. 10(1): 50-55.

10. Spurlock, M. 1997. ""Regulation of metabolism and growth during immune challenge: an overview of cytokine function."" J. Anim. Sci. 75: 1773-1783.

11. Klasing, K. 2007. ""Nutrition and the immune system."" Br. Poult. Sci. 48(5): 525-537.

12. Daskiran, M., Teeter, R., Fodge, D. and Hsiao, H. 2004. ""An Evaluation of Endo-β-D-mannanase (Hemicell) Effects on Broiler Performance and Energy Use in Diets Varying in β-mannan content."" Poultry Sci. 83: 662-668.

13. Pettey, L., Carter, S., Senne, B. and Shiver, J. 2002. ""Effects of β-mannanase addition to corn-soybean meal diets on growth performance, carcass traits, and nutrient digestibility of weaning and growing-finishing pig."" J. Anim. Sci. 80: 1012-1019

14. Owusu-Asiedu, A., Patience, J., Laarveld, B. et al. 2006. ""Effects of guar gum and cellulose on digest passage rate, ileal microbial populations, energy and protein digestibility, and performance of grower pigs."" J. Anim. Sci. 84: 843-852.

15. Pettey, L., Carter, S., Senne, B. and Shriver, J. ""Effects of HemicellT addition to nursery diets on growth performance of weanling pigs."" J. Anim. Sci. 77(Suppl.1): 195.

16. Gabler, N. and Spurlock, M. 2008. ""Integrating the immune system with the regulation of growth and efficiency."" J. Anim. Sci. 86: E64-E74.

17. Korver, D. 2006. ""Overview of the Immune Dynamics of the Digestive System."" J. Appl. Poultry Res. 15: 123-135.

Hemicell is a trademark of Eli Lilly and Company or its affiliates.