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Denagard® (tiamulin hydrogen fumarate)

Reduce the impact of two costly enteric diseases
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Hemicell® (β-mannanase)

β-Mannans: the problem component in soybean meal
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Kavault® (Avilamycin)

Reduce the incidence and overall severity of E. coli scours
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Paylean® (Ractopamine hydrochloride)

The choice for improved late-finishing performance and profitability

Prevacent PRRS

Protect Your Piglets
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Pulmotil® (tilmicosin)

Control respiratory disease associated with Actinobacillus pleuropneumoniae or Pasteurella multocida
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Pulmotil® AC (tilmicosin phosphate)

Go with the flow to help control swine respiratory disease (SRD)*
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Skycis® (Narasin)

Ionophores: Innovation for a productive future
Tylan® Injection

Tylan® Injection

Effective at treating swine arthritis* in valuable breeding animals and finishers
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Tylan® Premix (Tylosin phosphate)

Proven control of ileitis* for dependable, reliable results

Tylan® Soluble (Tylosin tartrate)

Effective control of ileitis

Prevacent PRRS

Protect Your Piglets


Porcine reproductive and respiratory syndrome (PRRS) is a costly disease that affects many stages of swine production. From reproductive failure in pregnant sows to respiratory disease in piglets, PRRS strikes swine operations right where it hurts most.

$1 BILLION estimated annual cost1 to the swine industry

$664 MILLION estimated production-related losses1

$478 MILLION estimated veterinary costs1

Prevacent PRRS - A Contemporary Solution for PRRS Today

Prevacent PRRS is a modified-live virus vaccine for the respiratory form of porcine reproductive and respiratory syndrome (PRRS) that is safe for use in piglets 2 weeks of age or older. With up to 26 weeks of demonstrated duration of immunity in pigs, Prevacent PRRS is the only Lineage 1 vaccine available on the market today.

CONTEMPORARY Lineage 1 vaccine

  • Prevacent PRRS is more homologous to Lineage 1 field strains MN184 and NC174 than any other modified-live PRRS vaccine on the market


  • Prevacent PRRS demonstrated protection against NADC20 and NC174 strains, resulting in a 93.2% reduction in lung lesions2,3

SAFE For your operation

  • Prevacent PRRS did not revert to virulence and exhibited limited transmission

CONTEMPORARY Lineage 1 vaccine

  • PRRS strains are classified into one of nine lineages based on their ORF-5 sequences. Over the years, these strains change and adapt, with the majority belonging to Lineage 14
  • Vaccine strains related to Lineages 5 and 8 were most prevalent during the 1980s and 1990s. However, since the mid-2000s, Lineage 1 PRRS strains have emerged as the most prevalent4
  • According to a presentation at the Allen D. Leman Swine Conference in September 2018, the majority of PRRS strains circulating in the U.S. are Lineage 15

10951 15 pacvac PrevacentDendogram


Two challenge studies6,7 were performed to evaluate the efficacy of Prevacent PRRS against two PRRSv field strains. On average, pigs vaccinated with Prevacent PRRS had a 93.2% reduction in lung lesions (Chart 1) and a 286.4% increase in average daily gain (ADG).


SAFE for your operation

During a 21-day study8, 20 pigs (10 controls/10 vaccinated) were commingled to evaluate the shedding and transmission characteristics of Prevacent PRRS.

Results showed:

  • 9 of 10 vaccinated pigs exhibited shedding as determined by positive nasal swab
  • Only 1 of 10 control pigs exhibited any positive samples, and this was only a single nasal swab of all 80 samples collected during the 21-day study

A three-site study9 with approximately 300 pigs per site was performed to determine the field safety of Prevacent PRRS.

Results showed:

  • No injection site reactions noted
  • Similar levels of adverse events as controls for each site
  • No vaccine-related adverse reactions noted

In a separate 80 pig study10, Prevacent PRRS demonstrated it did not revert to virulence.

The label contains complete use information, including cautions and warnings. Always read, understand and follow the label and use directions.

1Holtkamp, D.J. (2013). Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers. Journal of Swine Health and Production, 21(2), 72-84.

2Elanco Animal Health. Data on file.

3Elanco Animal Health. Data on file.

4Brar, M. S. (2015). Evolutionary diversification of type 2 porcine reproductive and respiratory syndrome virus. J. Gen. Virology, 96:1570-1580.

5Paploski, I. (2018). Making epidemiological sense out of large datasets of PRRS sequences. Proc. Allen D. Leman Conference, September 17, 2018.

6Elanco Animal Health. Data on file.

7Elanco Animal Health. Data on file.

8Elanco Animal Health. Data on file.

9Elanco Animal Health. Data on file.

10Elanco Animal Health. Data on file.

Prevacent, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates
Other company and product names are trademarks of their respective owners
© 2018 Elanco or its affiliates
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