Trifexis® (spinosad + milbemycin oxime)

3-in-1 protection

Just one tablet, once a month, every month, can protect your dog from fleas, heartworm disease and intestinal parasites all year long. Powerful parasite protection in one convenient tablet Just one beef-flavored tablet each month protects your dog against:

  • Heartworm disease
  • Fleas
  • Intestinal parasites: adult hookworm*, roundworm and whipworm

*Ancylostoma caninum

Is Trifexis right for your dog? If your dog spends time outdoors (or shares a home with outdoor pets), exposure to fleas, heartworm disease and intestinal parasites is a given. But even indoor dogs benefit from protection, particularly if they regularly visit the groomer or a boarding kennel. The American Heartworm Society (AHS) and the Companion Animal Parasite Council (CAPC) recommend annual testing and year-round heartworm disease prevention to ensure your dog is heartworm-free.1, 2

Three key threats to your dog’s health Insert “3-in-1 chart” graphic


  • Trifexis provides fast relief. It starts killing fleas within 30 minutes, before they can lay eggs and keeps working to prevent flea infestations all month long.
    • Fleas may cause extreme discomfort for your dog: scratching, chewing, biting, fur loss and restlessness.
    • Fleas are the source of flea allergy dermatitis (FAD), a common veterinary skin condition.
    • Severe infestations may cause anemia.3

Heartworm disease1

  • Heartworms are transmitted by mosquitoes and infection in dogs has been reported in all 50 states
  • Symptoms include coughing, sluggishness and difficulty breathing; however some dogs show no signs of any kind.
  • Treatment is difficult and costly, and complications may occur.

If left untreated it can be fatal to your dog Intestinal parasites

  • Intestinal parasites can cause dehydration, anemia, diarrhea and even death in puppies.4,5 Unfortunately, these parasites are all around, and your dog can contract them almost anywhere — on a daily walk, in your yard or at the local dog park.

[Canine Assistants Logo – TK] Elanco is committed to help pets live longer, healthier, higher-quality lives. To celebrate the relationship between humans and their dogs, Elanco, the makers of Trifexis, are sponsoring Canine Assistants. A purchase of Trifexis makes possible this sponsorship. For more information, visit [Insert Video]

What Does Your Pet Mean to You? Sean’s Compilation Video

Like Trifexis on Facebook for more information on pet health, helpful pet owner tips and special offers. To learn more about Trifexis, talk to your veterinarian or visit us online. [link to]

Important Safety Information

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, lethargy, pruritus, anorexia and diarrhea. To ensure heartworm prevention, dogs should be observed for one hour after administration. If vomiting occurs within one hour, redose. Puppies less than 14 weeks of age may experience a higher rate of vomiting.

Trifexis is indicated for the prevention of heartworm disease (Dirofilaria immitis). Trifexis kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), and the treatment and control of adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canis and Toxascaris leonina) and adult whipworm (Trichuris vulpis) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.

1American Heartworm Society Current Canine Guidelines, 2014

2 CAPC – General Guidelines,, Accessed 5 Apr 2016.

3CAPC – Fleas, CAPC – Fleas,, Accessed 5 Apr 2016

4CAPC – Roundworms,, Accessed 10 June 2015.

5CAPC – Whipworms, Accessed July 2015.

Trifexis, Elanco and the diagonal bar are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

© 2016 Eli Lilly and Company, its subsidiaries or affiliates.